Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

@article{Bohl2013MetastasisSI,
  title={Metastasis suppressors in breast cancers: mechanistic insights and clinical potential},
  author={Christopher R. Bohl and Sitaram Harihar and Warren L. Denning and Rahul Sharma and Danny R Welch},
  journal={Journal of Molecular Medicine},
  year={2013},
  volume={92},
  pages={13-30}
}
For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules—termed metastasis suppressors—are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known… CONTINUE READING