Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.

@article{RinkerSchaeffer2006MetastasisSP,
  title={Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.},
  author={Carrie W. Rinker-Schaeffer and James P. O'Keefe and Danny R Welch and Dan Theodorescu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 13},
  pages={3882-9}
}
Clinically and experimentally, primary tumor formation and metastasis are distinct processes — locally growing tumors can progress without the development of metastases. This observation prompted the hypothesis that the molecular processes regulating tumorigenicity and metastasis are distinguishable and could be targeted therapeutically. During the process… CONTINUE READING