Metastasis results from preexisting variant cells within a malignant tumor.

@article{Fidler1977MetastasisRF,
  title={Metastasis results from preexisting variant cells within a malignant tumor.},
  author={Isaiah J. Fidler and Margaret L. Kripke},
  journal={Science},
  year={1977},
  volume={197 4306},
  pages={
          893-5
        }
}
Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population. 
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