Metastasis-promoting immunity: when T cells turn to the dark side.

  title={Metastasis-promoting immunity: when T cells turn to the dark side.},
  author={Drew Mark Pardoll},
  journal={Cancer cell},
  volume={16 2},
While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion. 

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