Metastasis genes: A progression puzzle

  title={Metastasis genes: A progression puzzle},
  author={Ren{\'e} Bernards and Robert A Weinberg},
Most, if not all, human tumours develop through a succession of genetic and epigenetic changes that confer increasingly neoplastic (cancer-like) characteristics on cells. Indeed, this multistep process has been likened to darwinian evolution within the microcosm of living tissues, in which the units of selection are individual cells. A cell that possesses advantageous characteristics (ones that favour survival and proliferation) is selected to become the progenitor of a successor cell… CONTINUE READING
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