Metastasis genes: A progression puzzle

@article{Bernards2002MetastasisGA,
  title={Metastasis genes: A progression puzzle},
  author={Ren{\'e} Bernards and Robert A Weinberg},
  journal={Nature},
  year={2002},
  volume={418},
  pages={823-823}
}
Most, if not all, human tumours develop through a succession of genetic and epigenetic changes that confer increasingly neoplastic (cancer-like) characteristics on cells. Indeed, this multistep process has been likened to darwinian evolution within the microcosm of living tissues, in which the units of selection are individual cells. A cell that possesses advantageous characteristics (ones that favour survival and proliferation) is selected to become the progenitor of a successor cell… CONTINUE READING
Highly Cited
This paper has 48 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Metastasis: an early event in cancer progression

Journal of Cancer Research and Clinical Oncology • 2016
View 1 Excerpt