Metastasis associated genomic aberrations in stage II rectal cancer

  title={Metastasis associated genomic aberrations in stage II rectal cancer},
  author={Hong Zhao and Zhi-Zhou Shi and Rui Jiang and Dong-Bing Zhao and Hai-tao Zhou and Jianwei Liang and Xin-yu Bi and Jian-jun Zhao and Zhi-yu Li and Jianguo Zhou and Zhen Huang and Ye-fan Zhang and Jian Wang and Xin Xu and Yan Cai and Ming-Rong Wang and Yu Alex Zhang},
  journal={Genes \& Genomics},
Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real… 
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