Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2.

  title={Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2.},
  author={Be{\'a}ta Biri and Bence Kiss and R{\'o}bert Kir{\'a}ly and Gitta Schlosser and Orsolya L{\'a}ng and L{\'a}szl{\'o} Kőhidai and L{\'a}szl{\'o} F{\'e}s{\"u}s and L{\'a}szl{\'o} Nyitray},
  journal={The Biochemical journal},
  volume={473 1},
Transglutaminase-2 (TG2) is best known as a Ca(2+)-dependent cross-linking enzyme; however, some of its extracellular matrix-related functions are independent of its catalytic activity and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca(2+)-binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor survival in… CONTINUE READING

From This Paper

Topics from this paper.
2 Citations
25 References
Similar Papers


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 25 references

fibril deposition and requires syndecan-4/2 alpha5beta1 integrin co-signaling

  • J. Assi, G. Srivastava, A. Matta, M. C. Chang, P. G. Walfish, R. Ralhan
  • J Biol Chem
  • 2013

human transglutaminase 2 characterized by site-directed mutagenesis

  • J. A. Kenniston, G. P. Conley, D. J. Sexton, A. E. Nixon
  • FEBS J. 276,
  • 2013

Similar Papers

Loading similar papers…