Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2.

@article{Biri2016MetastasisassociatedSI,
  title={Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2.},
  author={Be{\'a}ta Biri and Bence Kiss and R{\'o}bert Kir{\'a}ly and Gitta Schlosser and Orsolya L{\'a}ng and L{\'a}szl{\'o} Kőhidai and L{\'a}szl{\'o} F{\'e}s{\"u}s and L{\'a}szl{\'o} Nyitray},
  journal={The Biochemical journal},
  year={2016},
  volume={473 1},
  pages={31-42}
}
Transglutaminase-2 (TG2) is best known as a Ca(2+)-dependent cross-linking enzyme; however, some of its extracellular matrix-related functions are independent of its catalytic activity and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca(2+)-binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor survival in… CONTINUE READING

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