Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model

@inproceedings{Duquette2015MetastasisassociatedMA,
  title={Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model},
  author={Mark A. Duquette and Peter M Sadow and Amjad Husain and Jennifer Nicole Sims and Zeus Andrea Antonello and Andrew H. Fischer and Chen Zhao Song and Elena Castellanos-Rizaldos and G. Mike Makrigiorgos and Junichi Kurebayashi and Vania Nos{\'e} and Paul van Hummelen and Roderick Terry Bronson and Michelle L Vinco and Thomas J. Giordano and Dora C Dias-Santagata and Pier Paolo Pandolfi and Carmelo Nucera},
  booktitle={Oncotarget},
  year={2015}
}
BRAF(V600E) mutation exerts an essential oncogenic function in many tumors, including papillary thyroid carcinoma (PTC). Although BRAF(V600E) inhibitors are available, lack of response has been frequently observed. To study the mechanism underlying intrinsic resistance to the mutant BRAF(V600E) selective inhibitor vemurafenib, we established short-term primary cell cultures of human metastatic/recurrent BRAF(V600E)-PTC, intrathyroidal BRAF(V600E)-PTC, and normal thyroid (NT). We also generated… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Molecular pathogenesis and mechanisms of thyroid cancer

Nature Reviews Cancer • 2013
View 10 Excerpts
Highly Influenced

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 10 Excerpts
Highly Influenced

Approach to the thyroid cancer patient with extracervical metastases.

The Journal of clinical endocrinology and metabolism • 2010
View 10 Excerpts
Highly Influenced

The landscape of somatic copynumber alteration across human cancers

R Beroukhim
2010
View 4 Excerpts
Highly Influenced

BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2014
View 1 Excerpt

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

The Cancer, Genome Atlas Research Network
Cell • 2014
View 2 Excerpts

Similar Papers

Loading similar papers…