Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

@article{Jorissen2009MetastasisAssociatedGE,
  title={Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer},
  author={R. Jorissen and P. Gibbs and M. Christie and S. Prakash and L. Lipton and J. Desai and D. Kerr and L. Aaltonen and Diego Arango and M. Kruh{\o}ffer and T. {\O}rntoft and C. L. Andersen and M. Gruidl and Vidya P. Kamath and S. Eschrich and T. Yeatman and O. Sieber},
  journal={Clinical Cancer Research},
  year={2009},
  volume={15},
  pages={7642 - 7651}
}
  • R. Jorissen, P. Gibbs, +14 authors O. Sieber
  • Published 2009
  • Medicine
  • Clinical Cancer Research
  • Purpose: Colorectal cancer prognosis is currently predicted from pathologic staging, providing limited discrimination for Dukes stage B and C disease. Additional markers for outcome are required to help guide therapy selection for individual patients. Experimental Design: A multisite single-platform microarray study was done on 553 colorectal cancers. Gene expression changes were identified between stage A and D tumors (three training sets) and assessed as a prognosis signature in stage B and C… CONTINUE READING

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