Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.

@article{Jorissen2009MetastasisAssociatedGE,
  title={Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.},
  author={Robert N. Jorissen and Peter Gibbs and Michael J. Christie and Saurabh Prakash and Leonard Lipton and Jayesh Desai and D. Kerr and Lauri A. Aaltonen and Diego Arango and Mogens Kruh{\o}ffer and Torben Falck Orntoft and Claus Lindbjerg Andersen and Mike Gruidl and V. P. Kamath and Steven Eschrich and Timothy J. Yeatman and Oliver M. Sieber},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 24},
  pages={
          7642-7651
        }
}
PURPOSE: Colorectal cancer prognosis is currently predicted from pathologic staging, providing limited discrimination for Dukes stage B and C disease. Additional markers for outcome are required to help guide therapy selection for individual patients. EXPERIMENTAL DESIGN: A multisite single-platform microarray study was done on 553 colorectal cancers. Gene expression changes were identified between stage A and D tumors (three training sets) and assessed as a prognosis signature in stage B and C… CONTINUE READING

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