Metastasis--an alternative hypothesis.

  title={Metastasis--an alternative hypothesis.},
  author={Emil J. Freireich and Razelle Kurzrock and Zeev Estrov},
  volume={103 8},
The currently accepted models of metastasis are inconsistent with many clinical observations of the natural history of cancer and its response to therapy. Specifically, the authors suggest that it is time for a "paradigm shift." It is time to reject the "local, regional, systemic hypothesis" of cancer and replace it with a hypothesis more consistent with the clinical facts, specifically, that cancer exists in many different forms (i.e. localized disease arising from locally acting carcinogens… CONTINUE READING