Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

@article{Kopfstein2005MetastasisCM,
  title={Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment},
  author={Lucie Kopfstein and Gerhard Christofori},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2005},
  volume={63},
  pages={449-468}
}
The fatality of cancer predominantly results from the dissemination of primary tumor cells to distant sites and the subsequent formation of metastases. During tumor progression, some of the primary tumor cells as well as the tumor microenvironment undergo characteristic molecular changes, which are essential for the metastatic dissemination of tumor cells. In this review, we will discuss recent insights into pro-metastatic events occurring in tumor cells themselves and in the tumor stroma… CONTINUE READING
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