Metastasis: Trading in mitochondria

  title={Metastasis: Trading in mitochondria},
  author={Isobel Barry},
  journal={Nature Reviews Cancer},
DNA (mtDNA) occur with high frequency in human tumours, their role, if any, in tumorigenesis is unclear. In their recent Science article, Ishikawa et al. describe how exchanging the mtDNA between mouse tumour cell lines revealed mutations that increase the metastatic potential of tumour cells. The authors used the mouse tumour cell lines P29, which has low metastatic potential, and A11, which has high metastatic potential, and created ‘cybrid’ cell lines by reciprocal exchange of the complete… CONTINUE READING