Metastable Pluripotent States in NOD Mouse Derived ES Cells

  title={Metastable Pluripotent States in NOD Mouse Derived ES Cells},
  author={Jacob Hanna and Styliani Markoulaki and Maisam Mitalipova and Albert Wu Cheng and John P. Cassady and Judith Staerk and Bryce W. Carey and Christopher Joachim Lengner and Ruth K. Foreman and Jennifer Love and Qing Gao and Jongpil Kim and Rudolf Jaenisch},
Embryonic stem (ES) cells are isolated from the inner cell mass (ICM) of blastocysts, whereas epiblast stem cells (EpiSCs) are derived from the post-implantation epiblast and display a restricted developmental potential. Here we characterize pluripotent states in the non-obese diabetic (NOD) mouse strain, which prior to this study was considered “non-permissive” for ES cell derivation. We find that NOD stem cells can be stabilized by providing constitutive expression of Klf4 or c-Myc or small… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 35 references

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 2 Excerpts

Similar Papers

Loading similar papers…