Metapopulation dynamics and spatial heterogeneity in cancer.

  title={Metapopulation dynamics and spatial heterogeneity in cancer.},
  author={Isabel Gonz{\'a}lez-Garc{\'i}a and Ricard V. Sol{\'e} and Jos{\'e} Sebasti{\'a}n D{\'a}vila Costa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 20},
With the advent of drugs targeting specific molecular defects in cancerous cells [Gorre, M. E., et al. (2001) Science 293, 876-880], it is important to understand the degree of genetic heterogeneity present in tumor cell populations and the rules that govern microdiversity in human cancer. Here, we first show that populations with different genotypes in genes influencing cell growth and programmed cell death coexist in advanced malignant tumors of the colon, exhibiting microsatellite… CONTINUE READING

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