Metaplasticity: tuning synapses and networks for plasticity

  title={Metaplasticity: tuning synapses and networks for plasticity},
  author={Wickliffe C. Abraham},
  journal={Nature Reviews Neuroscience},
Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that such plasticity be tightly regulated so that it occurs to the proper extent at the proper time. Activity-dependent mechanisms that have been collectively termed metaplasticity have evolved to help implement these essential computational constraints. Various intercellular signalling molecules can trigger lasting changes in the ability of synapses to express plasticity; their mechanisms of action are… CONTINUE READING
Highly Influential
This paper has highly influenced 49 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS