Metaplasticity: the plasticity of synaptic plasticity

@article{Abraham1996MetaplasticityTP,
  title={Metaplasticity: the plasticity of synaptic plasticity},
  author={Wickliffe C. Abraham and Mark F. Bear},
  journal={Trends in Neurosciences},
  year={1996},
  volume={19},
  pages={126-130}
}
In this paper, we review experimental evidence for a novel form of persistent synaptic plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it is not necessarily expressed as a change in the efficacy of normal synaptic transmission. Instead, it is manifest as a change in the ability to induce subsequent synaptic plasticity, such as long-term potentiation or depression. Thus, metaplasticity is a higher-order form of synaptic plasticity… Expand
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