Metaplasia and transdifferentiation: from pure biology to the clinic

@article{Slack2007MetaplasiaAT,
  title={Metaplasia and transdifferentiation: from pure biology to the clinic},
  author={J. Slack},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={369-378}
}
  • J. Slack
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases. 
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    References

    SHOWING 1-10 OF 102 REFERENCES
    How cells change their phenotype
    • D. Tosh, J. Slack
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2002
    • 395
    • PDF
    Transdifferentiation and metaplasia--switching cell types.
    • J. Slack, D. Tosh
    • Biology, Medicine
    • Current opinion in genetics & development
    • 2001
    • 184
    Stem Cell Biology
    • 227
    Plasticity of Adult Stem Cells
    • 1,193
    Nuclear reprogramming: A key to stem cell function in regenerative medicine
    • 135
    • PDF
    Adult stem cell plasticity: fact or artifact?
    • M. Raff
    • Biology, Medicine
    • Annual review of cell and developmental biology
    • 2003
    • 292
    • PDF
    Molecular basis of transdifferentiation of pancreas to liver
    • 399
    Differentiation of regenerating pancreatic cells into hepatocyte-like cells.
    • D. Scarpelli, M. Rao
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1981
    • 137
    • PDF
    Human embryonic stem cells: prospects for development
    • 246
    • PDF
    A role for chemistry in stem cell biology
    • 288