Metaplasia and transdifferentiation: from pure biology to the clinic

  title={Metaplasia and transdifferentiation: from pure biology to the clinic},
  author={Jonathan Mw Slack},
  journal={Nature Reviews Molecular Cell Biology},
  • J. Slack
  • Published 1 May 2007
  • Biology
  • Nature Reviews Molecular Cell Biology
Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases. 

Historical origins of transdifferentiation and reprogramming.

Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells

Induced transdifferentiation strategies to convert mature somatic cells to other mature cell types or progenitors are focused on, and the challenges that need to be met are summarized if the potential applications of trans Differentiation technology are to be achieved.

Metaplasia and somatic cell reprogramming

  • J. Slack
  • Biology
    The Journal of pathology
  • 2009
It is proposed that analogous technology, using the appropriate transcription factors, could be used to bring about transformation to cell types other than embryonic stem cells.

Extreme makeover: converting one cell into another.

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

This work has demonstrated that certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response.

Forcing cells to change lineages

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells

Induced pluripotent stem cells and the stability of the differentiated state

Recent progress is highlighted, and the implications of this work for the understanding of the relationship between the pluripotent and more differentiated cell states are highlighted.

Introduction: Gastrointestinal Stem Cells in Human Health and Disease

Since deregulation of stem cells may be responsible for premalignant or malignant lesions, a better understanding of the mechanisms responsible for their cellular proliferation, maturation, and differentiation is crucial for these pathologies to be treated.

Engineering Cell Fate for Tissue Regeneration by In Vivo Transdifferentiation

This work reviews the most relevant in vivo transdifferentiation studies in adult mammalian animal models, offering a critical assessment of this potentially powerful strategy for regenerative medicine.



How cells change their phenotype

This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

Transdifferentiation and metaplasia--switching cell types.

Plasticity of Adult Stem Cells

Nuclear reprogramming: A key to stem cell function in regenerative medicine

Evidence is provided that endogenous cells within the bone marrow have the capacity to incorporate into defective tissues and be reprogrammed and the potential for new gene expression patterns by BMDCs in recipient tissues holds promise for developing cellular therapies for both proliferative and post-mitotic tissues.

Adult stem cell plasticity: fact or artifact?

  • M. Raff
  • Biology
    Annual review of cell and developmental biology
  • 2003
There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy, and examples of plasticity where differentiated cells or their precursors can be reprogrammed by extracellular cues to alter their character in ways that could have important implications for cell Therapy and other forms of regenerative treatment.

Molecular basis of transdifferentiation of pancreas to liver

It is shown that pancreatic cells can be converted into hepatocytes by treatment with a synthetic glucocorticoid, dexamethasone, and that a proportion of the hepatocytes arises directly from differentiated exocrine-like cells, with no intervening cell division.

Differentiation of regenerating pancreatic cells into hepatocyte-like cells.

  • D. ScarpelliM. Rao
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1981
An in vivo model in the Syrian golden hamster in which regenerating pancreatic cells are converted into hepatocyte-like cells, as evidenced by the presence of albumin, peroxisomes, and a variety of morphological markers suggests that, given the proper stimulus, regenerating cells in adult pancreas can be redirected into a totally different pathway of differentiation.

Human embryonic stem cells: prospects for development

Technical advances in the propagation and manipulation of human ES cells have improved the authors' understanding of their growth and differentiation, providing the potential to investigate early human development and to develop new clinical therapies.

A role for chemistry in stem cell biology

Cell-based phenotypic and pathway-specific screens of natural products and synthetic compounds have recently provided a number of small molecules that can be used to selectively control stem cell proliferation and differentiation, which may provide new insights into stem cell biology.