Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990–2012

@article{Stammschulte2015MetamizoleA,
  title={Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990–2012},
  author={Thomas Stammschulte and W-D. Ludwig and Bernd Muehlbauer and Elisabeth Bronder and Ursula M. Gundert-Remy},
  journal={European Journal of Clinical Pharmacology},
  year={2015},
  volume={71},
  pages={1129-1138}
}
In 1986, the risk of agranulocytosis prompted German authorities to restrict the indications for metamizole use. After an initial decline, prescriptions increased from <20 million defined daily doses in 1990 to >140 million in 2012. Concurrently, spontaneous reports of agranulocytosis increased from about 10 in 1990 to >50 in 2012. In this study, reports were analyzed to identify targets for risk minimization measures. Reports of suspected metamizole-induced agranulocytosis (neutrophils <0.5… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Do older patients take more drugs and are they at higher risk of adverse drug reactions? What do our spontaneous reports say

  • T Stammschulte, H Pachl, U Gundert-Remy
  • Drug Saf
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…