Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats.

Abstract

The most commonly used drugs against pain act by inhibiting the cyclooxygenases (COXs). Metamizol (dipyrone) inhibits the COXs and is widely used in Europe and Latin America as a non-opioid analgesic. One target of metamizol and other non-opioid analgesics is the periaqueductal grey matter (PAG), where they trigger descending inhibition of spinal… (More)
DOI: 10.1002/j.1532-2149.2011.00057.x

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Cite this paper

@article{Escobar2012MetamizolAN, title={Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats.}, author={William Escobar and Karina D. Ramirez and Concepci{\'o}n {\'A}vila and Roberto Limongi and Horacio Vanegas and Elsa V{\'a}zquez}, journal={European journal of pain}, year={2012}, volume={16 5}, pages={676-89} }