Metals in our minds: therapeutic implications for neurodegenerative disorders.

@article{Doraiswamy2004MetalsIO,
  title={Metals in our minds: therapeutic implications for neurodegenerative disorders.},
  author={P. Murali Doraiswamy and Anne E Finefrock},
  journal={The Lancet. Neurology},
  year={2004},
  volume={3 7},
  pages={431-4}
}
BACKGROUND Abnormal interactions of copper or iron in the brain with metal-binding proteins (such as amyloid-beta peptide [Abeta] or neuromelanin) that lead to oxidative stress have emerged as important potential mechanisms in brain ageing and neurodegenerative disorders. Although a controlled study of desferrioxamine in Alzheimer's disease(AD) had some promising results, concerns about toxicity and brain delivery have limited trials of traditional chelators. The therapeutic significance of… CONTINUE READING

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