Metals and free radicals in neurodegeneration.

  title={Metals and free radicals in neurodegeneration.},
  author={Charles W. Olanow and Gary W. Arendash},
  journal={Current opinion in neurology},
  volume={7 6},
Substantial evidence has accumulated implicating metals and free radicals in the pathogenesis of the major neurodegenerative disorders (Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis). Metal-induced oxidant stress can damage critical biological molecules and initiate a cascade of events including mitochondrial dysfunction, excitotoxicity, and a rise in cytosolic free calcium, leading to cell death. In Parkinson's disease and Alzheimer's disease there is evidence of… CONTINUE READING


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