Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology

@inproceedings{Wong2014MetalsAC,
  title={Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology},
  author={Bruce X Wong and Y. H. Hung and Ashley I. Bush and James A Duce},
  booktitle={Front. Aging Neurosci.},
  year={2014}
}
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron, and zinc are abnormally accumulated and distributed in the aging brain. These metal ions can adversely contribute to the progression of AD. Dysregulation of cholesterol metabolism… CONTINUE READING