Metals, toxicity and oxidative stress.

@article{Valko2005MetalsTA,
  title={Metals, toxicity and oxidative stress.},
  author={Mari{\'a}n Valko and Harry Morris and Mark T. D. Cronin},
  journal={Current medicinal chemistry},
  year={2005},
  volume={12 10},
  pages={
          1161-208
        }
}
Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen and nitrogen species, is reviewed. Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl homeostasis. Lipid peroxides, formed by the attack of radicals on polyunsaturated fatty acid residues of phospholipids, can further react with redox metals finally producing mutagenic and carcinogenic… 

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References

SHOWING 1-10 OF 389 REFERENCES

Mutagenesis

  • A. Natarajan
  • Biology, Medicine
    Cytogenetic and Genome Research
  • 1998
SCE increased at all the tested concentrations except the lowest dose, while that low dose induced a significant effect on the induction of chromosomal aberrations in the germ cells, indicating that rifampicin has a potential clastogenic effect.

[Oncogene].

Recently, many cellular oncogenes were identified in human cancerous cells by the DNA transfection method, some of which were found to contain sequences related with already known viral oncogenees.

Neurotoxicology

MRI revealed lesions of the central portions of the corpus callosum as well as the deep white matter of the left frontal lobe, which is possible to consider this case as MarchiafavaBignami disease.

The Metabolic Basis Of Inherited Disease.

This volume, more than most, explains the contributions of the laboratory to clinical medicine, and shedding light on fundamental metabolic sequences and biologic mechanisms.

Carcinogenesis

  • W. Gardner
  • Medicine, Biology
    The Yale Journal of Biology and Medicine
  • 1961
This book will be a useful reference book for research endocrinologists or those involved in the measurement of hormones in blood or for its critical evaluation of methods rather than a description of a particular method.

Blood.

  • P. Sperryn
  • Medicine, Biology
    British journal of sports medicine
  • 1989
The blood's functions include oxygen transport from lungs to tissues in exchange for waste carbon dioxide, transport of hormones, nutrients and waste products between organs, clotting to seal off haemorrhage and the transport of white cells to combat infection.

Leukemia

  • C. Geary
  • Medicine, Biology
    British Journal of Cancer
  • 1984
Your friend is lucky to have someone like you who wants to learn more about what they’re going through, because the survival rate of those diagnosed with leukemia really depends on the type with which they're diagnosed.

Arterioscler. Thromb

  • Vasc. Biol
  • 2000

J. Mol. Cell. Biochem

  • J. Mol. Cell. Biochem
  • 2004
...