Metals, toxicity and oxidative stress.

  title={Metals, toxicity and oxidative stress.},
  author={Mari{\'a}n Valko and HaroldP. Morris and Mark Timothy David Cronin},
  journal={Current medicinal chemistry},
  volume={12 10},
Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen and nitrogen species, is reviewed. Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl homeostasis. Lipid peroxides, formed by the attack of radicals on polyunsaturated fatty acid residues of phospholipids, can further react with redox metals finally producing mutagenic and carcinogenic… CONTINUE READING
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