Metallothionein response to stress in rats: role in free radical scavenging.

  title={Metallothionein response to stress in rats: role in free radical scavenging.},
  author={Juan Hidalgo and Luis Campmany and Miquel Borr{\'a}s and Justine S. Garvey and Antonio Armario},
  journal={The American journal of physiology},
  volume={255 4 Pt 1},
The possibility that liver metallothionein (MT) can function as an antioxidant in vivo has been studied in the rat. It was found that the stress of food and water deprivation with or without physical immobilization consistently increased liver lipid peroxidation (LLP), suggesting that liver MT induction by stress might be related to the stress-induced LLP. This was supported by results with the lipid peroxidation promoter dimethyl sulfoxide (DMSO) and the natural antioxidant vitamin E. Whereas… CONTINUE READING
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