Metallothionein polymorphisms in pathological processes.
@article{Raudenska2014MetallothioneinPI,
title={Metallothionein polymorphisms in pathological processes.},
author={Martina Raudenska and Jarom{\'i}r Gumulec and Ondrej Podlaha and Mark{\'e}ta Sztalmachov{\'a} and Petr Babula and Tom{\'a}{\vs} Eckschlager and Vojtěch Adam and Ren{\'e} Kizek and Michal Masař{\'i}k},
journal={Metallomics : integrated biometal science},
year={2014},
volume={6 1},
pages={
55-68
}
}Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic…
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References
SHOWING 1-10 OF 130 REFERENCES
Metallothioneins and cancer.
- BiologyCurrent protein & peptide science
- 2009
The role of MTs as a tumor disease marker or as a cause of resistance in cancer treatment is reviewed and discussed, and some analytical methods that were developed to detect MTs are described.
Metallothioneins and zinc in cancer diagnosis and therapy
- BiologyDrug metabolism reviews
- 2012
The structure and function of MTs are strongly dependent on Zn2+ redox state and its binding to proteins and their importance for chemoresistance is also mentioned.
Roles of the metallothionein family of proteins in the central nervous system
- BiologyBrain Research Bulletin
- 2001
Mammalian metallothioneins: properties and functions.
- BiologyMetallomics : integrated biometal science
- 2012
In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal- based drugs.
Metallothioneins in human tumors and potential roles in carcinogenesis.
- Biology, MedicineMutation research
- 2003
Prognostic significance of metallothionein in human gastrointestinal cancer.
- Medicine, BiologyClinical cancer research : an official journal of the American Association for Cancer Research
- 2002
Overexpression of MT in intestinal tissue of colorectal cancer patients is a prognostic marker for a poor overall survival, and in gastric cancer, MT expression in the gastric mucosa is not of prognostic significance, which emphasizes the clinical relevance of this multifunctional metalloprotein in coloreCTal carcinogenesis and therapy.
Regulation of metallothionein gene expression by oxidative stress and metal ions.
- BiologyBiochemical pharmacology
- 2000
Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population
- BiologyBiogerontology
- 2006
The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition.
Metallothionein--a promising tool for cancer diagnostics.
- BiologyBratislavske lekarske listy
- 2009
Automated electrochemical detection of metallothionein allows its serial analysis in a very small volume with excellent sensitivity, reliability and reproducibility and therefore it can be considered as a new tool for cancer diagnosis.




