Metallothionein-overexpression as a prognostic factor for progression and survival in melanoma. A prospective study on 520 patients.

BACKGROUND Metallothioneins (MTs) are ubiquitous proteins with high affinity for heavy metal ions, e.g. zinc, copper and cadmium. In the last decade it has been shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and radiotherapy, and with a poor prognosis. OBJECTIVES To examine the role of MT… (More)