Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2.

@article{Sens2003MetallothioneinI1,
  title={Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2.},
  author={Donald A Sens and Michael R. Rossi and Seongmi Park and Volkan Gurel and Joginder Nath and Scott Garrett and Mary Ann Sens and Seema Somji},
  journal={Journal of toxicology and environmental health. Part A},
  year={2003},
  volume={66 21},
  pages={2031-46}
}
Studies have shown that metallothionein (MT) is overexpressed in some human bladder cancers and that overexpression can predict treatment response to neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy. In the present study the UROtsa cell line, a model of normal human urothelium, was used to determine the expression of the human MT-1 and MT-2… CONTINUE READING