Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc.

@article{Beattie2000MetallothioneinIE,
  title={Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc.},
  author={John H. Beattie and A M Wood and Paul Trayhurn and Bharat Jasani and Anne Vincent and Graeme H. McCormack and Adrian K. West},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={278 4},
  pages={
          R1082-9
        }
}
  • J. Beattie, A. Wood, +4 authors A. West
  • Published 1 April 2000
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Metallothionein (MT) is thought to have an antioxidant function and is strongly expressed during activation of thermogenesis and increased oxidative stress in brown adipose tissue (BAT). Localization and regulation of MT expression in BAT was therefore investigated in rats and mice. Immunohistochemical analysis of BAT from rats exposed to 4 degrees C for 24 h showed that MT and uncoupling protein 1 (UCP1) were coexpressed in differentiated adipocytes, and both cytoplasmic and nuclear… 
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Metallothionein gene expression and secretion in white adipose tissue.
TLDR
It is concluded that WAT may be a significant site of MT production; within adipocytes, MT could play an antioxidant role in protecting fatty acids from damage.
Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue
TLDR
This study showed that the expressions of MT1 and MT2 genes in WAT are regulated by nutritional status, and the regulation may be independent of total zinc concentration.
CL316,243 and Cold Stress Induce Heterogeneous Expression of UCP1 mRNA and Protein in Rodent Brown Adipocytes
  • S. Cinti, R. Cancello, +5 authors D. Ricquier
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2002
TLDR
Evidence is presented that the Harlequin phenomenon is particularly evident after acute and chronic cold stimulus and after administration of a specific β3-adrenoceptor agonist, and mRNA in situ expression confirmed the UCP1 non-homogeneous pattern of gene activation under conditions of adrenergic stimulus.
Antioxidant property of metallothionein in fasted mice.
Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes
TLDR
The data indicates that mature 3T3-L1 adipocytes are responsive to isoproterenol and induce UCP1 expression and activity, and provides a model for further pharmaceutical and nutraceutical investigation of U CP1 in 3T 3-L 1s.
The autocrine role of FGF21 in cultured adipocytes.
TLDR
FGF21 plays an autocrine role and increases glucose uptake after β-adrenergic stimulation of cultured brown WT-1 adipocytes, and is consistent with the observation that PD 173074 decreased Iso-induced glucose uptake in the WT- 1 adipocytes.
Expression of two metallothionein genes in different brain regions of common carp.
TLDR
The expression pattern of two metallothionein genes in response to temperature shock and exposure to Cd(2+) was investigated in the brain of common carp in whole-animal experiments, and MT-2 was induced significantly more strongly in the olfactory lobe than in the cerebellum or midbrain.
METALLOTHIONEIN EXPRESSION AND ROLES IN THE CENTRAL NERVOUS SYSTEM
TLDR
Brain tissue damage and neuro degeneration during pathological conditions and the accompanying mortality and clinical symptoms are altogether significantly increased inMT-I+II deficient mice, while the opposite is observed after medical MT-II treatment and in MT-I overexpressing mice.
Response of the adipose tissue transcriptome to dihydrotestosterone in mice.
TLDR
It is suggested that DHT consistently modulates genes involved in the regulation of adipogenesis in retroperitoneal adipose tissue of both male and female animals.
Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
TLDR
Evidence is provided that the protumorigenic hypoxia-inducible transcription factor-1 α (HIF-1α) is essential for induction of MT-1 by hypoxIA, but not zinc, and that association of these important transcription factors in a multiprotein complex represents a common strategy to control unique sets of hypoxial-inducer genes in both normal and diseased tissue.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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