Metallothionein in human atherosclerotic lesions: a scavenger mechanism for reactive oxygen species in the plaque?


Oxidative stress is important in the genesis of atherosclerotic lesions. The extracellular effects of reactive oxygen species (ROS), such as oxidative modification of lipoproteins and upregulation of matrix degrading enzymes, are considered crucial in this context. The effects of ROS are counteracted by antioxidant scavenging systems; metallothioneins (MTs… (More)
DOI: 10.1007/s004280000260

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