Metallothionein functions and structural characteristics.

  title={Metallothionein functions and structural characteristics.},
  author={Emilio Carpen{\'e} and Giulia Andreani and Gloria Isani},
  journal={Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements},
  volume={21 Suppl 1},
Metallothioneins (MTs) are low molecular weight proteins characterized by a high cysteine content and give rise to metal-thiolate clusters. Most MTs have two metal clusters containing three and four bivalent metal ions, respectively. The MT gene family in mammals consists of four subfamilies designated MT-1 through MT-4. MT-3 is expressed predominantly in brain and MT-4 in differentiating stratified squamous epithelial cells. Many reports have addressed MT structure and function, but despite… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
35 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 35 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Prion protein protects against zinc-mediated cytotoxicity by modifying intracellular exchangeable zinc compartimentation in cultured cells

  • W Rachidi, F Chimienti, M Aouffen, P Guiraud, M Seve, A. Aavier
  • Quim Clin 2007;26(S1):19
  • 2007
1 Excerpt

Zinc-binding proteins (metallothionein and a-2 macroglobulin) and immunosenescence. Exp Gerontol 2006;41:1094–107

  • E Mocchegiani, L Costarelli, R Giacconi, C Cipriano, E Muti, M. Malavolta
  • ARTICLE IN PRESS E. Carpenè et al. / Journal of…
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…