Metallothionein expression in human neoplasia

@article{Theocharis2004MetallothioneinEI,
  title={Metallothionein expression in human neoplasia},
  author={S. Theocharis and A. Margeli and J. Klijanienko and G. Kouraklis},
  journal={Histopathology},
  year={2004},
  volume={45}
}
The metallothionein family is a class of low‐molecular‐weight, cysteine‐rich proteins with high affinity for metal ions. Four major isoforms (metallothionein‐1, ‐2, ‐3, and ‐4) have been identified in mammals, involved in many pathophysiological processes, including metal ion homeostasis and detoxification, protection against oxidative damage, cell proliferation and apoptosis, drug and radiotherapy resistance and several aspects of the carcinogenic process. In the present review we examine the… Expand
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