Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice.

Abstract

To clarify the physiological role(s) of metallothionein (MT) in carcinogenesis, we studied the susceptibility of MT-null mice to chemically mediated carcinogenesis in the 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage carcinogenesis model. The MT-null mice were subjected to a single topical application of… (More)

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@article{Suzuki2003MetallothioneinDE, title={Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice.}, author={Junko Suzuki and Noriko Nishimura and Baoxu Zhang and Yoko Nakatsuru and Shizuko Kobayashi and Masahiko Satoh and Chiharu Tohyama}, journal={Carcinogenesis}, year={2003}, volume={24 6}, pages={1123-32} }