Metallothionein blocks oxidative DNA damage in vitro

  title={Metallothionein blocks oxidative DNA damage in vitro},
  author={Wei Qu and Jingbo Pi and Michael P. Waalkes},
  journal={Archives of Toxicology},
The role of metallothionein (MT) in mitigation of oxidative DNA damage (ODD) induced by either cadmium (Cd) or the direct oxidant hydrogen peroxide (H2O2) was systematically examined using MT-I/II double knockout (MT-null) or MT-competent wild-type (WT) cells. Both toxicants were much more lethal to MT-null cells (Cd LC50 = 6.6 μM; H2O2 LC50 = 550 μM) than… CONTINUE READING