Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells.


Metallothionein-III (MT-III), a metal-binding protein, is associated with resistance to neuronal injury. However, the underlying mechanism for its effects remains unclear. We therefore examined whether MT-III can induce VEGF expression and promote neuroprotective effects in brain endothelial bEND.3 cells. MT-III significantly induced VEGF mRNA and protein… (More)
DOI: 10.1016/j.bbrc.2008.02.059


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