Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis.

@article{Sun2016Metallothionein1GFS,
  title={Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis.},
  author={Xiaofang Sun and Xiaohua Niu and Ruochan Chen and Wenyin He and De Chen and Rui Kang and Daolin Tang},
  journal={Hepatology},
  year={2016},
  volume={64 2},
  pages={488-500}
}
UNLABELLED Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide and currently has the fastest rising incidence of all cancers. Sorafenib was originally identified as an inhibitor of multiple oncogenic kinases and remains the only approved systemic therapy for advanced HCC. However, acquired resistance to sorafenib has been found in HCC patients, which results in poor prognosis. Here, we show that metallothionein (MT)-1G is a critical regulator and promising… CONTINUE READING
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