Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide.

@article{Penkowa2002Metallothionein1P,
  title={Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide.},
  author={Milena Penkowa and Mercedes Giralt and Jordi Camats and Juan Hidalgo},
  journal={The Journal of comparative neurology},
  year={2002},
  volume={444 2},
  pages={174-89}
}
6-Aminonicotinamide (6-AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes. Metallothionein 1+2 (MT-1+2) are neuroprotective factors in the central nervous system (CNS), and to determine the roles for MT after 6-AN, we have examined transgenic mice overexpressing MT-1 (TgMTI* mice) after an i.p. injection with 6-AN. In control mice injected with 6-AN, astrocytes in specific gray matter areas of the brainstem showed degeneration. Reactive astrocytes surrounded the… CONTINUE READING

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