Metallothionein: an intracellular protein to protect against cadmium toxicity.

@article{Klaassen1999MetallothioneinAI,
  title={Metallothionein: an intracellular protein to protect against cadmium toxicity.},
  author={Curtis D. Klaassen and Jie A. Liu and Supratim Choudhuri},
  journal={Annual review of pharmacology and toxicology},
  year={1999},
  volume={39},
  pages={267-94}
}
Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding proteins. MT genes are readily induced by various physiologic and toxicologic stimuli. Because the cysteines in MT are absolutely conserved across species, it was suspected that the cysteines are necessary for function and MT is essential for life. In attempts to determine the function(s) of MT, studies have been performed using four different experimental paradigms: (a) animals injected with chemicals known to induce… CONTINUE READING
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