Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells.

@article{Susanto1998MetallothioneinGA,
  title={Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells.},
  author={Irawan Susanto and Shawn E Wright and Richard S. Lawson and Charnae E Williams and Susan M. Deneke},
  journal={The American journal of physiology},
  year={1998},
  volume={274 2 Pt 1},
  pages={L296-300}
}
Both glutathione (γ-glutamylcysteinylglycine; GSH) and the metalloprotein metallothionein (MT) are composed of approximately one-third cysteine. Both have antioxidant activity and are induced by oxidant stresses and heavy metals. Intracellular cysteine levels may depend on uptake and reduction of extracellular cystine. GSH synthesis can be limited by the activity of the [Formula: see text] cystine transport system, which is induced by oxidants and other stresses. MT is induced by treatments… CONTINUE READING