Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.

@article{Behrendtsen1992MetalloproteinasesME,
  title={Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.},
  author={Ole Behrendtsen and Caroline M. Alexander and Zena Werb},
  journal={Development},
  year={1992},
  volume={114 2},
  pages={
          447-56
        }
}
The maintenance and developmental remodeling of extracellular matrix is crucial to such processes as uterine implantation and the cell migratory events of morphogenesis. When mouse blastocysts are placed in culture they adhere to extracellular matrix, and trophoblast giant cells migrate out onto the matrix and degrade it. The secretion of functional proteinases by developing mouse embryos increases dramatically at the time of implantation. By zymography we identified the major secreted gelatin… CONTINUE READING

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