Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction of MMP-1 by myeloma cells.

@article{Barill1997MetalloproteinasesIM,
  title={Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction of MMP-1 by myeloma cells.},
  author={Sophie Barill{\'e} and Cam{\'e}lia Akhoundi and Madeleine Collette and M P Mellerin and M. J. Rapp and J. L. Harousseau and R{\'e}gis Bataille and Martine Amiot},
  journal={Blood},
  year={1997},
  volume={90 4},
  pages={1649-55}
}
Multiple myeloma is a very devastating cancer with a high capacity to destroy bone matrix. Matrix metalloproteinases (MMPs) play a critical role in bone remodeling and tumor invasion. In this study, we have investigated the involvement of interstitial collagenase (MMP-1) and gelatinases (MMP-2 and MMP-9) in the biology of multiple myeloma. We show (1) that… CONTINUE READING