Metalloproteinases in endochondral bone formation: appearance of tissue inhibitor-resistant metalloproteinases.

@article{MikuniTakagaki1987MetalloproteinasesIE,
  title={Metalloproteinases in endochondral bone formation: appearance of tissue inhibitor-resistant metalloproteinases.},
  author={Yuko Mikuni-Takagaki and Yuan Shan Cheng},
  journal={Archives of biochemistry and biophysics},
  year={1987},
  volume={259 2},
  pages={576-88}
}
Dissected embryonic chick limbs release neutral metalloproteinases during endochondral bone development. These enzymes degrade cartilage proteoglycan and gelatin in culture medium. We found the enzymes active in the medium conditioned by explants of the region adjacent to the bone marrow cavity (cavity-surround). These enzymes degrade proteoglycan (PG) and/or gelatin. These spontaneously active enzymes are resistant to serum and tissue proteinase inhibitors, alpha 2-macroglobulin, and cartilage… CONTINUE READING