Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.

@article{ToftHansen2006MetalloproteinasesCB,
  title={Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.},
  author={Henrik Toft-Hansen and Richard Buist and Xuejun Sun and Angela Schellenberg and James Peeling and Trevor Owens},
  journal={Journal of immunology},
  year={2006},
  volume={177 10},
  pages={7242-9}
}
Inflammatory leukocytes infiltrate the CNS parenchyma in neuroinflammation. This involves cellular migration across various structures associated with the blood-brain barrier: the vascular endothelium, the glia limitans, and the perivascular space between them. Leukocytes accumulate spontaneously in the perivascular space in brains of transgenic (Tg) mice that overexpress CCL2 under control of a CNS-specific promoter. The Tg mice show no clinical symptoms, even though leukocytes have crossed… CONTINUE READING