Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia.

@article{Nuttall2007MetalloproteinasesAE,
  title={Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia.},
  author={Robert K. Nuttall and Claudia Silva and Walter J. Hader and Amit Bar-Or and Kamala D. Patel and Dylan R W Edwards and V. Wee Yong},
  journal={Glia},
  year={2007},
  volume={55 5},
  pages={516-26}
}
Microglia are resident immune cells within the central nervous system (CNS). They become activated following neurological insults and increase their expression of cytokines. Also elevated in CNS injuries are proteases, including matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs). The spectrum of metalloproteinase members expressed by microglia and by the systemic leukocytes that infiltrate the injured CNS is unknown, as are their functions. We determined the… CONTINUE READING

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