Metalloproteinases and their natural inhibitors in inflammation and immunity

  title={Metalloproteinases and their natural inhibitors in inflammation and immunity},
  author={Rama Khokha and Aditya Narasimha Murthy and Ashley Weiss},
  journal={Nature Reviews Immunology},
Over the past 50 years, steady growth in the field of metalloproteinase biology has shown that the degradation of extracellular matrix components represents only a fraction of the functions performed by these enzymes and has highlighted their fundamental roles in immunity. Metalloproteinases regulate aspects of immune cell development, effector function, migration and ligand–receptor interactions. They carry out ectodomain shedding of cytokines and their cognate receptors. Together with their… CONTINUE READING
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Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1

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