Corpus ID: 34745065

Metalloproteinases (MMPs) of the extracellular matrix in Dentistry

@inproceedings{Prado2016MetalloproteinasesO,
  title={Metalloproteinases (MMPs) of the extracellular matrix in Dentistry},
  author={Vanesa Pereira Prado and Natalia Asquino and Delmira Apell{\'a}niz and Luis Alexandro Bueno Rossy and Gabriela Trejo Tapia and Ronell Bologna Molina},
  year={2016}
}
La mayoría de los tejidos del organismo se encuentran en un constante proceso de renovación, modulado por una vasta cantidad de proteínas que inducen la síntesis y degradación tisular a lo largo del tiempo. Las metaloproteinasas de la matriz extracelular (MMPs) son una familia de 25 endopeptidasas zinc dependientes encargadas de escindir los componentes inmediatos de la matriz extracelular (MEC). Ciertas metaloproteinasas de la matriz extracelular, especialmente MMP-2 y MMP-9, se ven implicadas… Expand

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References

SHOWING 1-10 OF 36 REFERENCES
Metaloproteinasas de la matriz en Odontología y sus consideraciones desde el campo de la química computacional
TLDR
There is positive correlation between deregulation of certain MMPs and progression of certain oral diseases, this has boosted in silico identifying and designing effective inhibitors for these proteins, based on structure-activity relationship analysis and molecular docking computational. Expand
Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.
TLDR
Variations in MMP2 and MMP3 are associated with periapical lesion formation in individuals with untreated deep carious lesions, and future studies could help predict host susceptibility to developing periAPical lesions. Expand
Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.
TLDR
Teeth treated with calcium hydroxide root canal dressing exhibited a lower percentage of bacterial contamination, a lower MMP expression, and a more organized extracellular matrix, unlike those treated in a single visit, which suggests that calcium Hydroxide might be beneficial in tissue repair processes. Expand
Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis.
TLDR
MMP-8 was shown as a possible marker for progressive bone loss in peri-implantitis and PISF samples from control group showed no positive reactions to any collagenase. Expand
Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response
TLDR
Apical lesions display an oxidant imbalance along with increased activity of matrix metalloproteinase-2 and -9 and might contribute to AAP progression and be useful as potential biomarkers for chair-side complementary diagnostic of apical status in GCF. Expand
Increased Matrix Metalloproteinase-2 and Bone Sialoprotein Response to Human Coronal Caries
TLDR
The results indicate that MMP-2 and BSP may be actively secreted by odontoblasts in response to carious insult and accumulation in the caries-affected dentinal tubules may indicate their potential involvement in the host defense mechanism which results in calcification of regions affected by the carious process. Expand
ROL DE LAS METALOPROTEINASAS Y SUS INHIBIDORES EN PATOLOGÍA TUMORAL
TLDR
Due to their role in cancer biology, MMPs are potential targets for future therapeutic strategies of this malignant disease. Expand
Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients
TLDR
The expression of MMP-2 and -9 might contribute to periodontal physiological and pathological processes, and the degree of M MP-9 expression and activity are predictive indicators relevant to the progression of periodontitis. Expand
Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.
TLDR
Treatment of LAgP with SRP and systemic antibiotics was effective in reducing local levels of specific MMPs in African-American individuals, which correlated positively with some clinical parameters. Expand
Matrix metalloproteinase-9 expression in alveolar extraction sockets of Zoledronic acid-treated rats.
  • D. Basi, P. Hughes, +5 authors R. Gopalakrishnan
  • Medicine
  • Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • 2011
TLDR
ZA reduced bone mineralization within tooth extraction sockets, suggesting aberrant bone healing, and ZA increases the amount and enzymatic activity of MMP-9, while apparently not altering the amount of TIMP1 within extraction sockets. Expand
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