Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis

@article{Milner2006MetalloproteinaseAI,
  title={Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis},
  author={Jennifer M. Milner and Andrew D Rowan and Timothy E Cawston and David A. Young},
  journal={Arthritis Research & Therapy},
  year={2006},
  volume={8},
  pages={R142 - R142}
}
Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the metalloproteinase family, specifically the matrix metalloproteinases (MMPs) and a group of proteinases with a disintegrin and metalloproteinase domain with thrombospondin motifs (ADAMTS). Chondrocytes are the only cell type embedded in the cartilage ECM, and cell-matrix interactions can influence gene expression and cell behaviour. Thus… CONTINUE READING
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