Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.

  title={Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.},
  author={Alicia R. Folgueras and Teresa Vald{\'e}s-S{\'a}nchez and Elena Llano and Luis Armando Men{\'e}ndez and Ana Baamonde and Bristol L Denlinger and Carlos Belmonte and Luc{\'i}a Ju{\'a}rez and Ana Lastra and Olivia Garc{\'i}a-Su{\'a}rez and Aurora Astudillo and Martina Kirstein and Alberto M Pend{\'a}s and Isabel Fari{\~n}as and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 38},
Peripheral interactions between nociceptive fibers and mast cells contribute to inflammatory pain, but little is known about mechanisms mediating neuro-immune communication. Here we show that metalloproteinase MT5-MMP (MMP-24) is an essential mediator of peripheral thermal nociception and inflammatory hyperalgesia. We report that MT5-MMP is expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia and that Mmp24-deficient mice display enhanced sensitivity to noxious thermal… CONTINUE READING


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