Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

Abstract

Purpose Coloboma is a sight-threatening congenital eye disease caused by a failure in optic fissure (OF) closure. The aim of this study was to investigate the role of Adamts16, a metalloproteinase, in OF closure. Methods RNA in situ hybridization was used to examine the expression of Adamts16 in developing mouse and zebrafish eyes. Morpholino knockdowns… (More)
DOI: 10.1167/iovs.17-22827

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