Metalloproteases and rotator cuff disease.

  title={Metalloproteases and rotator cuff disease.},
  author={Angelo Del Buono and Francesco Oliva and Umile Giuseppe Longo and Scott Alan Rodeo and John Orchard and Vincenzo Denaro and Nicola Maffulli},
  journal={Journal of shoulder and elbow surgery},
  volume={21 2},
The molecular changes occurring in rotator cuff tears are still unknown, but much attention has been paid to better understand the role of matrix metalloproteinases (MMP) in the development of tendinopathy. These are potent enzymes that, once activated, can completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediatethe development of painful tendinopathy and tendon rupture. To control the local activity of activated proteinases, the same cells… CONTINUE READING